High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease

High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin...

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發表在:Redox Biol
Main Authors: Alhasson, Firas, Seth, Ratanesh Kumar, Sarkar, Sutapa, Kimono, Diana A., Albadrani, Muayad S., Dattaroy, Diptadip, Chandrashekaran, Varun, Scott, Geoffrey I., Raychoudhury, Samir, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Chatterjee, Saurabh
格式: Artigo
語言:Inglês
出版: Elsevier 2018
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006523/
https://ncbi.nlm.nih.gov/pubmed/29660503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.04.002
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