Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent

SsnB previously showed a promising role to lessen liver inflammation observed in a mouse model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its role in attenuating NAFLD associated fibrosis. Using both in vivo and in vitro approaches, the study probed the possible...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Principais autores: Dattaroy, Diptadip, Seth, Ratanesh Kumar, Sarkar, Sutapa, Kimono, Diana, Albadrani, Muayad, Chandrashekaran, Varun, Al Hasson, Firas, Singh, Udai P., Fan, Daping, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Chatterjee, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193950/
https://ncbi.nlm.nih.gov/pubmed/30194936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.08.040
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