Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

Metabolic oxidative stress via CYP2E1 can act as a second hit in NASH progression. Our previous studies have shown that oxidative stress in NASH causes higher leptin levels and induces purinergic receptor X7 (P2X7r). We tested the hypothesis that higher circulating leptin due to CYP2E1-mediated oxid...

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Détails bibliographiques
Publié dans:Biochim Biophys Acta
Auteurs principaux: Chandrashekaran, Varun, Das, Suvarthi, Seth, Ratanesh Kumar, Dattaroy, Diptadip, Alhasson, Firas, Michelotti, Gregory, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Chatterjee, Saurabh
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988689/
https://ncbi.nlm.nih.gov/pubmed/26474534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.10.009
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