NADPH Oxidase–Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment

The molecular events that link NADPH oxidase activation and the induction of Toll-like receptor (TLR)-4 recruitment into hepatic lipid rafts in nonalcoholic steatohepatitis (NASH) are unclear. We hypothesized that in liver, NADPH oxidase activation is key in TLR4 recruitment into lipid rafts, which...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Das, Suvarthi, Alhasson, Firas, Dattaroy, Diptadip, Pourhoseini, Sahar, Seth, Ratanesh Kumar, Nagarkatti, Mitzi, Nagarkatti, Prakash S., Michelotti, Gregory A., Diehl, Anna Mae, Kalyanaraman, Balaraman, Chatterjee, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483465/
https://ncbi.nlm.nih.gov/pubmed/25989356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.03.024
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