Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B., Xie, Guanhua, Michelotti, Gregory A., Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319738/
https://ncbi.nlm.nih.gov/pubmed/25658689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116780
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