Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B., Xie, Guanhua, Michelotti, Gregory A., Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319738/
https://ncbi.nlm.nih.gov/pubmed/25658689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116780
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