Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

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Опубликовано в: :PLoS One
Главные авторы: Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B., Xie, Guanhua, Michelotti, Gregory A., Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319738/
https://ncbi.nlm.nih.gov/pubmed/25658689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116780
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