Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

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Foilsithe in:PLoS One
Main Authors: Pourhoseini, Sahar, Seth, Ratanesh Kumar, Das, Suvarthi, Dattaroy, Diptadip, Kadiiska, Maria B., Xie, Guanhua, Michelotti, Gregory A., Nagarkatti, Mitzi, Diehl, Anna Mae, Chatterjee, Saurabh
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319738/
https://ncbi.nlm.nih.gov/pubmed/25658689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116780
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