M1 Polarization Bias and Subsequent Nonalcoholic Steatohepatitis Progression Is Attenuated by Nitric Oxide Donor DETA NONOate via Inhibition of CYP2E1-Induced Oxidative Stress in Obese Mice

Activation of M1 macrophages in nonalcoholic steatohepatitis (NASH) is produced by several external or endogenous factors: inflammatory stimuli, oxidative stress, and cytokines are known. However, any direct role of oxidative stress in causing M1 polarization in NASH has been unclear. We hypothesize...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Seth, Ratanesh Kumar, Das, Suvarthi, Pourhoseini, Sahar, Dattaroy, Diptadip, Igwe, Stephen, Ray, Julie Basu, Fan, Daping, Michelotti, Gregory A., Diehl, Anna Mae, Chatterjee, Saurabh
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2015
Témata:
Gastrointestinal, Hepatic, Pulmonary, and Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279102/
https://ncbi.nlm.nih.gov/pubmed/25347994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.218131
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