Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) is the common pathophysiological process resulting from chronic liver inflammation and oxidative stress. Although significant research has been carried out on the role of leptin-induced NADPH oxidase in fibrogenesis, the molecular mechanisms th...

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Dettagli Bibliografici
Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Dattaroy, Diptadip, Pourhoseini, Sahar, Das, Suvarthi, Alhasson, Firas, Seth, Ratanesh Kumar, Nagarkatti, Mitzi, Michelotti, Gregory A., Diehl, Anna Mae, Chatterjee, Saurabh
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
Soggetti:
Liver and Biliary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329476/
https://ncbi.nlm.nih.gov/pubmed/25501551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00346.2014
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