M(1)-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Highly selective positive allosteric modulators (PAMs) of the M(1) subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for improving cognitive function in patients suffering from Alzheimer’s disease and schizophrenia. However, excessive activation of M(1) is known t...

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Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Moran, Sean P., Dickerson, Jonathan W., Cho, Hyekyung P., Xiang, Zixiu, Maksymetz, James, Remke, Daniel H., Lv, Xiaohui, Doyle, Catherine A., Rajan, Deepa H., Niswender, Colleen M., Engers, Darren W., Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006294/
https://ncbi.nlm.nih.gov/pubmed/29581537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0033-9
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