M(1)-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Highly selective positive allosteric modulators (PAMs) of the M(1) subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for improving cognitive function in patients suffering from Alzheimer’s disease and schizophrenia. However, excessive activation of M(1) is known t...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Neuropsychopharmacology
Главные авторы: Moran, Sean P., Dickerson, Jonathan W., Cho, Hyekyung P., Xiang, Zixiu, Maksymetz, James, Remke, Daniel H., Lv, Xiaohui, Doyle, Catherine A., Rajan, Deepa H., Niswender, Colleen M., Engers, Darren W., Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2018
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006294/
https://ncbi.nlm.nih.gov/pubmed/29581537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0033-9
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы