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M(1)-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Highly selective positive allosteric modulators (PAMs) of the M(1) subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for improving cognitive function in patients suffering from Alzheimer’s disease and schizophrenia. However, excessive activation of M(1) is known t...
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| 出版年: | Neuropsychopharmacology |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer International Publishing
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6006294/ https://ncbi.nlm.nih.gov/pubmed/29581537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0033-9 |
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