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PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems
Positive allosteric modulators (PAMs) of the M(1) subtype of muscarinic acetylcholine receptor have attracted intense interest as an exciting new approach for improving the cognitive deficits in schizophrenia and Alzheimer’s disease. Recent evidence suggests that the presence of intrinsic agonist ac...
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| Опубликовано в: : | ACS Chem Neurosci |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6146053/ https://ncbi.nlm.nih.gov/pubmed/29683646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00106 |
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