Hyperhaploidy is a Novel High-Risk Cytogenetic Subgroup in Multiple Myeloma

Hyperhaploid clones (24-34 chromosomes) were identified in 33 patients with multiple myeloma (MM), identifying a novel numerical cytogenetic subgroup. Strikingly, all hyperhaploid karyotypes were found to harbor monosomy 17p, the single most important risk stratification lesion in MM. A catastrophic...

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Veröffentlicht in:Leukemia
Hauptverfasser: Sawyer, Jeffrey R., Tian, Erming, Shaughnessy, John D., Epstein, Joshua, Swanson, Charles M., Stangeby, Collin, Hale, Christine L., Parr, Lewis, Lynn, Michael, Sammartino, Gael, Lukacs, Janet L., Stein, Caleb, Bailey, Clyde, Zangari, Maurizio, Davies, Faith E., Van Rhee, Frits, Barlogie, Bart, Morgan, Gareth J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005364/
https://ncbi.nlm.nih.gov/pubmed/27694925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.253
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