Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease

Multiple myeloma (MM) is a B-cell malignancy driven in part by increasing copy number alterations (CNAs) during disease progression. Prognostically significant CNAs accumulate during clonal evolution and include gains of 1q21 and deletions of 17p, among others. Unfortunately, the mechanisms underlyi...

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Auteurs principaux: Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Epstein, Joshua, Johann, Donald J., Swanson, Charles M., Lukacs, Janet L., Johnson, Marian, Binz, Regina, Boast, Angela, Sammartino, Gael, Usmani, Saad, Zangari, Maurizio, Waheed, Sarah, van Rhee, Frits, Barlogie, Bart
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990913/
https://ncbi.nlm.nih.gov/pubmed/24497533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-12-546077
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