An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome

Patients with multiple myeloma (MM) accumulate adverse copy number aberrations (CNAs), gains of 1q21, and 17p deletions during disease progression. A subset of these patients develops heightened 1q12 pericentromeric instability and jumping translocations of 1q12 (JT1q12), evidenced by increased copy...

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Publié dans:Blood Cancer J
Auteurs principaux: Sawyer, Jeffrey R., Tian, Erming, Walker, Brian A., Wardell, Christopher, Lukacs, Janet L., Sammartino, Gael, Bailey, Clyde, Schinke, Carolina D., Thanendrarajan, Sharmilan, Davies, Faith E., Morgan, Gareth J., Barlogie, Bart, Zangari, Maurizio, van Rhee, Frits
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689064/
https://ncbi.nlm.nih.gov/pubmed/31399558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-019-0226-4
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