Hyperhaploidy is a Novel High-Risk Cytogenetic Subgroup in Multiple Myeloma

Hyperhaploid clones (24-34 chromosomes) were identified in 33 patients with multiple myeloma (MM), identifying a novel numerical cytogenetic subgroup. Strikingly, all hyperhaploid karyotypes were found to harbor monosomy 17p, the single most important risk stratification lesion in MM. A catastrophic...

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Publicado no:Leukemia
Main Authors: Sawyer, Jeffrey R., Tian, Erming, Shaughnessy, John D., Epstein, Joshua, Swanson, Charles M., Stangeby, Collin, Hale, Christine L., Parr, Lewis, Lynn, Michael, Sammartino, Gael, Lukacs, Janet L., Stein, Caleb, Bailey, Clyde, Zangari, Maurizio, Davies, Faith E., Van Rhee, Frits, Barlogie, Bart, Morgan, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005364/
https://ncbi.nlm.nih.gov/pubmed/27694925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.253
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