Evidence for a Novel Mechanism for Gene Amplification in Multiple Myeloma: 1q12 Pericentromeric Heterochromatin Mediates Breakage-Fusion-Bridge Cycles of a 1q12~23 Amplicon

Gene amplification is defined as a copy number (CN) increase in a restricted region of a chromosome arm, and is a mechanism for acquired drug resistance and oncogene activation. In multiple myeloma (MM), high CNs of genes in a 1q12~23 amplicon have been associated with disease progression and poor p...

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Main Authors: Sawyer, Jeffrey R., Tian, Erming, Thomas, Edward, Koller, Mark, Stangeby, Colin, Sammartino, Gael, Goosen, Linda, Swanson, Charles, Binz, Regina Lichti, Barlogie, Bart, Shaughnessy, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738438/
https://ncbi.nlm.nih.gov/pubmed/19744130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07869.x
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