Mesenchymal stem cells gene signature in high-risk myeloma bone marrow linked to suppression of distinct IGFBP2-expressing small adipocytes

Recent studies suggest that multiple myeloma (MM) induces proliferation and expansion of bone marrow (BM) mesenchymal stem cells (MSCs), but others showed that MM cells induce MSC senescence. To clarify the interaction between MM and MSCs, we exploited our established MSC gene signature to identify...

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Veröffentlicht in:Br J Haematol
Hauptverfasser: Mehdi, Syed J., Johnson, Sarah K., Epstein, Joshua, Zangari, Maurizio, Qu, Pingping, Hoering, Antje, van Rhee, Frits, Schinke, Carolina, Thanendrarajan, Sharmilan, Barlogie, Bart, Davies, Faith E., Morgan, Gareth J., Yaccoby, Shmuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361704/
https://ncbi.nlm.nih.gov/pubmed/30408155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15669
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