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Codon usage of highly expressed genes affects proteome-wide translation efficiency

Although the genetic code is redundant, synonymous codons for the same amino acid are not used with equal frequencies in genomes, a phenomenon termed “codon usage bias.” Previous studies have demonstrated that synonymous changes in a coding sequence can exert significant cis effects on the gene’s ex...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Frumkin, Idan, Lajoie, Marc J., Gregg, Christopher J., Hornung, Gil, Church, George M., Pilpel, Yitzhak
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003480/
https://ncbi.nlm.nih.gov/pubmed/29735666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719375115
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