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Dynamic changes in translational efficiency are deduced from codon usage of the transcriptome

Translation of a gene is assumed to be efficient if the supply of the tRNAs that translate it is high. Yet high-abundance tRNAs are often also at high demand since they correspond to preferred codons in genomes. Thus to fully model translational efficiency one must gauge the supply-to-demand ratio o...

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Hlavní autoři: Gingold, Hila, Dahan, Orna, Pilpel, Yitzhak
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488229/
https://ncbi.nlm.nih.gov/pubmed/22941644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks772
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