Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models

BACKGROUND: Huntington’s disease (HD) is a progressive neurodegenerative disorder associated with aging, caused by an expanded polyglutamine (polyQ) repeat within the Huntingtin (HTT) protein. In HD, degeneration of the striatum and atrophy of the cortex are observed while cerebellum is less affecte...

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Veröffentlicht in:J Huntingtons Dis
Hauptverfasser: Franich, Nicholas R., Basso, Manuela, André, Emily A., Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L., Yeung, Sylvia Y., Osmand, Alexander, Zeitlin, Scott O., Ratan, Rajiv R., Thompson, Leslie M., Steffan, Joan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: IOS Press 2018
Schlagworte:
Research Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002862/
https://ncbi.nlm.nih.gov/pubmed/29843246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170274
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