Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models

BACKGROUND: Huntington’s disease (HD) is a progressive neurodegenerative disorder associated with aging, caused by an expanded polyglutamine (polyQ) repeat within the Huntingtin (HTT) protein. In HD, degeneration of the striatum and atrophy of the cortex are observed while cerebellum is less affecte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Huntingtons Dis
Main Authors: Franich, Nicholas R., Basso, Manuela, André, Emily A., Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L., Yeung, Sylvia Y., Osmand, Alexander, Zeitlin, Scott O., Ratan, Rajiv R., Thompson, Leslie M., Steffan, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2018
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002862/
https://ncbi.nlm.nih.gov/pubmed/29843246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170274
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados