BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-mediated Degradation

Adhesion G-protein coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N-termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) t...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Zhu, Dan, Osuka, Satoru, Zhang, Zhaobin, Reichert, Zachery R., Yang, Liquan, Kanemura, Yonehiro, Jiang, Ying, You, Shuo, Zhang, Hanwen, Devi, Narra S., Bhattacharya, Debanjan, Takano, Shingo, Gillespie, G. Yancey, Macdonald, Tobey, Tan, Chalet, Nishikawa, Ryo, Nelson, William G., Olson, Jeffrey J., Van Meir, Erwin G.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002773/
https://ncbi.nlm.nih.gov/pubmed/29894688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.006
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