PDTM-27. EPIGENETIC LOSS OF BAI1 EXPRESSION IN CEREBELLAR GRANULE NEURON PRECURSORS INACTIVATES THE p53 TUMOR SUPPRESSOR AND FACILITATES MEDULLOBLASTOMA FORMATION IN THE CEREBELLUM

Adhesion G-protein coupled receptors (ADGRs) are transmembrane proteins involved in cell-cell/matrix interactions. We show ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in human medulloblastomas through a methyl-CpG binding protein 2 (MBD2)-dep...

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Vydáno v:Neuro Oncol
Hlavní autoři: Zhu, Dan, Osuka, Satoru, Zhang, Zhaobin, Reichert, Zachery, Kanemura, Yonehiro, Nishikawa, Ryo, G. Nelson, William, J. Olson, Jeffrey, Van Meir, Erwin G
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217668/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.868
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