BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-mediated Degradation

Adhesion G-protein coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N-termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) t...

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Publicado en:Cancer Cell
Autores principales: Zhu, Dan, Osuka, Satoru, Zhang, Zhaobin, Reichert, Zachery R., Yang, Liquan, Kanemura, Yonehiro, Jiang, Ying, You, Shuo, Zhang, Hanwen, Devi, Narra S., Bhattacharya, Debanjan, Takano, Shingo, Gillespie, G. Yancey, Macdonald, Tobey, Tan, Chalet, Nishikawa, Ryo, Nelson, William G., Olson, Jeffrey J., Van Meir, Erwin G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002773/
https://ncbi.nlm.nih.gov/pubmed/29894688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.006
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