Indirect presentation in the thymus limits naive and regulatory T‐cell differentiation by promoting deletion of self‐reactive thymocytes

Acquisition of T‐cell central tolerance involves distinct pathways of self‐antigen presentation to thymocytes. One pathway termed indirect presentation requires a self‐antigen transfer step from thymic epithelial cells (TECs) to bone marrow‐derived cells before the self‐antigen is presented to thymo...

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Bibliographische Detailangaben
Veröffentlicht in:Immunology
Hauptverfasser: Yap, Jin Yan, Wirasinha, Rushika C., Chan, Anna, Howard, Debbie R., Goodnow, Christopher C., Daley, Stephen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002238/
https://ncbi.nlm.nih.gov/pubmed/29411880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12904
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