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Intraclonal competition limits regulatory T cell fate determination in the thymus
Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3(+)CD4(+) regulatory T (T(reg)) cells is required for preventing autoimmunity. However, the role of T cell receptor (TCR) specificity in thymic T(reg) cell development remains controversial. To address th...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756247/ https://ncbi.nlm.nih.gov/pubmed/19430476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1739 |
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