IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

Regulatory T (T reg) cells, a specialized subset of CD4(+) T cells, are essential to prevent fatal autoimmunity. Expression of the T reg lineage-defining transcription factor Foxp3, and therefore their differentiation in the thymus, is dependent upon T cell receptor (TCR) and interleukin-2 (IL-2) si...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Hemmers, Saskia, Schizas, Michail, Azizi, Elham, Dikiy, Stanislav, Zhong, Yi, Feng, Yongqiang, Altan-Bonnet, Grégoire, Rudensky, Alexander Y.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829602/
https://ncbi.nlm.nih.gov/pubmed/31434685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190993
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