IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

Regulatory T (T reg) cells, a specialized subset of CD4(+) T cells, are essential to prevent fatal autoimmunity. Expression of the T reg lineage-defining transcription factor Foxp3, and therefore their differentiation in the thymus, is dependent upon T cell receptor (TCR) and interleukin-2 (IL-2) si...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Hemmers, Saskia, Schizas, Michail, Azizi, Elham, Dikiy, Stanislav, Zhong, Yi, Feng, Yongqiang, Altan-Bonnet, Grégoire, Rudensky, Alexander Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829602/
https://ncbi.nlm.nih.gov/pubmed/31434685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190993
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados