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Indirect presentation in the thymus limits naive and regulatory T‐cell differentiation by promoting deletion of self‐reactive thymocytes

Acquisition of T‐cell central tolerance involves distinct pathways of self‐antigen presentation to thymocytes. One pathway termed indirect presentation requires a self‐antigen transfer step from thymic epithelial cells (TECs) to bone marrow‐derived cells before the self‐antigen is presented to thymo...

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Vydáno v:Immunology
Hlavní autoři: Yap, Jin Yan, Wirasinha, Rushika C., Chan, Anna, Howard, Debbie R., Goodnow, Christopher C., Daley, Stephen R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002238/
https://ncbi.nlm.nih.gov/pubmed/29411880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12904
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