Indirect presentation in the thymus limits naive and regulatory T‐cell differentiation by promoting deletion of self‐reactive thymocytes

Acquisition of T‐cell central tolerance involves distinct pathways of self‐antigen presentation to thymocytes. One pathway termed indirect presentation requires a self‐antigen transfer step from thymic epithelial cells (TECs) to bone marrow‐derived cells before the self‐antigen is presented to thymo...

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Bibliographic Details
Published in:Immunology
Main Authors: Yap, Jin Yan, Wirasinha, Rushika C., Chan, Anna, Howard, Debbie R., Goodnow, Christopher C., Daley, Stephen R.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002238/
https://ncbi.nlm.nih.gov/pubmed/29411880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12904
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