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IL-2 prevents deletion of developing T-regulatory cells in the thymus
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8– CCR7+ Helios+ thym...
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| Publicado en: | Cell Death Differ |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5442470/ https://ncbi.nlm.nih.gov/pubmed/28362433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.38 |
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