IL-2 prevents deletion of developing T-regulatory cells in the thymus

In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8– CCR7+ Helios+ thym...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Hu, Daniel Y, Wirasinha, Rushika C, Goodnow, Christopher C, Daley, Stephen R
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
Assuntos:
Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442470/
https://ncbi.nlm.nih.gov/pubmed/28362433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.38
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares