Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells

The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wave 1 deletion is defined as apoptosis within nascent αβ T-cell antigen receptor (TCR)-signalled thymocytes that lack CCR7 expression. The antigen-presenting cell (APC) typ...

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Vydáno v:Cell Death Differ
Hlavní autoři: Wirasinha, Rushika C., Chan, Anna, Yap, Jin Yan, Hu, Daniel Y., Teh, Charis E., Gray, Daniel H. D., Goodnow, Christopher C., Daley, Stephen R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224288/
https://ncbi.nlm.nih.gov/pubmed/31019259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0331-8
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