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Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells
The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wave 1 deletion is defined as apoptosis within nascent αβ T-cell antigen receptor (TCR)-signalled thymocytes that lack CCR7 expression. The antigen-presenting cell (APC) typ...
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| Pubblicato in: | Cell Death Differ |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7224288/ https://ncbi.nlm.nih.gov/pubmed/31019259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0331-8 |
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