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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Sci |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Royal Society of Chemistry
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6001276/ https://ncbi.nlm.nih.gov/pubmed/29997876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01262h |
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