Navigating the conformational landscape of G protein–coupled receptor kinases during allosteric activation

G protein–coupled receptors (GPCRs) are essential for transferring extracellular signals into carefully choreographed intracellular responses controlling diverse aspects of cell physiology. The duration of GPCR-mediated signaling is primarily regulated via GPCR kinase (GRK)-mediated phosphorylation...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yao, Xin-Qiu, Cato, M. Claire, Labudde, Emily, Beyett, Tyler S., Tesmer, John J. G., Grant, Barry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625036/
https://ncbi.nlm.nih.gov/pubmed/28808053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807461
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