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A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases
G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated GPCRs and initiate their desensitization. Many prior studies suggest that activated GPCRs dock to an allosteric site on the GRKs and thereby stimulate kinase activity. The extreme N-terminal region of GRKs is clearly involved i...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719358/ https://ncbi.nlm.nih.gov/pubmed/19364770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809544200 |
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