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Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors (GPCRs) to initiate receptor desensitization. In addition to the canonical phosphoacceptor site of the kinase domain, activated receptors bind to a distinct docking site that confers higher affinity and act...

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Detalhes bibliográficos
Main Authors: Huang, Chih-chin, Orban, Tivadar, Jastrzebska, Beata, Palczewski, Krzysztof, Tesmer, John J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069497/
https://ncbi.nlm.nih.gov/pubmed/21265573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101606e
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