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Molecular basis for activation of G protein-coupled receptor kinases
G protein-coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal structures of GRK6 in which regions known to be critical for receptor phosphorylation...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957210/ https://ncbi.nlm.nih.gov/pubmed/20729810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.206 |
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