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Molecular basis for activation of G protein-coupled receptor kinases

G protein-coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal structures of GRK6 in which regions known to be critical for receptor phosphorylation...

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Bibliografski detalji
Glavni autori: Boguth, Cassandra A, Singh, Puja, Huang, Chih-chin, Tesmer, John J G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957210/
https://ncbi.nlm.nih.gov/pubmed/20729810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.206
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