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Computation of Conformational Coupling in Allosteric Proteins

In allosteric regulation, an effector molecule binding a protein at one site induces conformational changes, which alter structure and function at a distant active site. Two key challenges in the computational modeling of allostery are the prediction of the structure of one allosteric state starting...

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Detalles Bibliográficos
Main Authors: Kidd, Brian A., Baker, David, Thomas, Wendy E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720451/
https://ncbi.nlm.nih.gov/pubmed/19714199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000484
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