Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q

Neomorphic mutation R140Q in the metabolic enzyme isocitrate dehydrogenase 2 (IDH2) is found to be a driver mutation in cancers. Recent studies revealed that allosteric inhibitors could selectively inhibit IDH2/R140Q and induce differentiation of TF-1 erythroleukemia and primary human AML cells. How...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Jiao, Yang, Jie, Sun, Xianqiang, Wang, Zhongming, Cheng, Xiaolan, Lu, Wuguang, Cai, Xueting, Hu, Chunping, Shen, Xu, Cao, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705638/
https://ncbi.nlm.nih.gov/pubmed/29184081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16427-w
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