טוען...
Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...
שמור ב:
| הוצא לאור ב: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6393305/ https://ncbi.nlm.nih.gov/pubmed/30649466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1314 |
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