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Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced ATP noncovalently but were rendered ineffective due to the de...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5431542/ https://ncbi.nlm.nih.gov/pubmed/28484248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01491-z |
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