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Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors
The development of a new series of apoptosis signal-regulating kinase 1 (ASK1) inhibitors is described. Starting from purine, pyrimidine and quinazoline scaffolds identified by high throughput screening, we used tools of structure-based drug design to develop a series of potent kinase inhibitors, in...
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| Publicado en: | Bioorg Med Chem Lett |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5999544/ https://ncbi.nlm.nih.gov/pubmed/29277458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.12.026 |
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