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In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors
[Image: see text] We present the outcome of an in silico high throughput screen (HTS) and optimization of a small molecule Unc-51-Like Kinase 1 (ULK1) inhibitor hit, SR-17398, with an indazole core. Docking studies guided design efforts that led to inhibitors with increased activity vs ULK1 (IC(50)...
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| Gepubliceerd in: | ACS Med Chem Lett |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2017
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5733266/ https://ncbi.nlm.nih.gov/pubmed/29259744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00344 |
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