Development of an HTS-Compatible Assay for the Discovery of ASK1 Signalosome Inhibitors Using AlphaScreen Technology

Genetic target validation studies have demonstrated that the apoptosis signal-regulating kinase 1 (ASK1) represents an important target for the treatment of rheumatoid arthritis, cardiac diseases, and several neurodegenerative disorders. To identify small-molecule inhibitors of ASK1, we have develop...

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Autores principales: Sturchler, Emmanuel, Chen, Weimin, Spicer, Timothy, Hodder, Peter, McDonald, Patricia, Duckett, Derek
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2014
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025566/
https://ncbi.nlm.nih.gov/pubmed/24831789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2013.558
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