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Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases

[Image: see text] Tankyrases (TNKSs) are poly(ADP-ribose)polymerases (PARPs) that are overexpressed in several clinical cancers. They regulate elongation of telomeres, regulate the Wnt system, and are essential for the function of the mitotic spindle. A set of 2-arylquinazolin-4-ones has been design...

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Detaylı Bibliyografya
Asıl Yazarlar: Nathubhai, Amit, Wood, Pauline J., Lloyd, Matthew D., Thompson, Andrew S., Threadgill, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2013
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027532/
https://ncbi.nlm.nih.gov/pubmed/24900625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400260b
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