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Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases
[Image: see text] Tankyrases (TNKSs) are poly(ADP-ribose)polymerases (PARPs) that are overexpressed in several clinical cancers. They regulate elongation of telomeres, regulate the Wnt system, and are essential for the function of the mitotic spindle. A set of 2-arylquinazolin-4-ones has been design...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2013
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027532/ https://ncbi.nlm.nih.gov/pubmed/24900625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400260b |
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