Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors

Pyruvate dehydrogenase kinases 1–4 (PDK1-4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure and cancer. We reported earlier two novel pan-PDK inhibitors PS8 [4-((5-hydroxyisoindolin-2-yl)sulfonyl)benzene-1,3-diol] (1) a...

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Publicado no:J Med Chem
Main Authors: Tso, Shih-Chia, Lou, Mingliang, Wu, Cheng-Yang, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Williams, Noelle S., Wynn, R. Max, Qi, Xiangbing, Chuang, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996997/
https://ncbi.nlm.nih.gov/pubmed/28085286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01540
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