Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

We report the crystal structures of the phosporylated pyruvate dehydrogenase (E1p) component of the human pyruvate dehydrogenase complex (PDC). The complete phosphorylation at Ser264-α (site 1) of a variant E1p protein was achieved using robust pyruvate dehydrogenase kinase 4 free of the PDC core. W...

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Bibliographic Details
Main Authors: Kato, Masato, Max Wynn, R, Chuang, Jacinta L, Tso, Shih-Chia, Machius, Mischa, Li, Jun, Chuang, David T.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849990/
https://ncbi.nlm.nih.gov/pubmed/19081061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.010
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