Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

Lignende værker

• Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
  af: Kato, Masato, et al.
  Udgivet: (2005)
• Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex
  af: Brautigam, Chad A., et al.
  Udgivet: (2009)
• Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops
  af: Kato, Masato, et al.
  Udgivet: (2008)
• Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate
  af: Li, Jun, et al.
  Udgivet: (2009)
• Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors
  af: Tso, Shih-Chia, et al.
  Udgivet: (2017)