Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Background: Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and remodeling of the lung vasculature. Adenosine signaling through the ADORA2B receptor has previously been implicated in diseas...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Mertens, Tinne C. J., Hanmandlu, Ankit, Tu, Ly, Phan, Carole, Collum, Scott D., Chen, Ning-Yuan, Weng, Tingting, Davies, Jonathan, Liu, Chen, Eltzschig, Holger K., Jyothula, Soma S. K., Rajagopal, Keshava, Xia, Yang, Guha, Ashrith, Bruckner, Brian A., Blackburn, Michael R., Guignabert, Christophe, Karmouty-Quintana, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992271/
https://ncbi.nlm.nih.gov/pubmed/29910735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00555
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